Getting started: download and install RX (Mac or Windows), activate your license, and open the RX Audio Editor (Standard/Advanced only). Import your audio file, let the Repair Assistant analyze it, and apply the suggested repairs. For basic noise reduction, the entire process takes 5-10 minutes including learning the interface.
The learning curve depends on your needs. The Repair Assistant makes basic cleanup accessible to beginners in 15 minutes. Learning spectral editing, understanding each module's parameters, and developing an ear for when each tool is appropriate takes 5-10 hours over several sessions. Tutorials on YouTube and iZotope's own learning resources are excellent.
For workflow integration, RX works as both a standalone application and as plugins within your DAW (Pro Tools, Logic, Reaper, Audacity via bridge). The plugin workflow lets you apply RX repairs without leaving your editing environment. Most podcasters use the standalone editor for heavy repair and plugins for quick fixes during editing.
Practical tip: always repair audio before editing, not after. Removing noise, clicks, and reverb is more effective on raw audio than on audio that's already been compressed, EQ'd, or processed. Make RX the first stop in your audio production chain, then move to your DAW for editing and mixing.